I've always looked for meaningful work that also connects with my talents and passions. I've had three distinct careers in my life so far, and I feel a fourth one coming on in the next 3-5 years.
Other than these, I a not sure there is anything I truly could not do without. I've lived through quite a bit in my life, and I've learned that happiness is an "inside job". Life is what I make it. I tend to face challenges and adapt to them, be it illness, death of loved one, loss of material things, loss of money, etc. I've lived here in the US and in another country, raised two children as a divorced single father, come to terms with my sexuality, healed from childhood abuse and trauma, and more.